To understand if the apoptotic functions of DRP-1 are important for age-dependent muscle degeneration as it is for dystrophin-dependent muscle degeneration, we analyzed drp-1(tm1108) mutant worms expressing either the wild-type drp-1 transgene (drp-1(+)) or the drp-1 transgene with the CED-3 cleavage site mutated (drp-1(D118A)) supposed to be inefficient in apoptosis (Fig. 3A). The gene discussed is DMD; the disease is Skeletal muscle atrophy.