TNF and allergic disease: Cytokine and hormone systems play an important role in inflammatory processes and manifest in the form of fever, allergy, etc. The inhibition of cyclooxygenase-2 (COX2) and Inducible nitric oxide synthase (iNO)S enzyme activity, the signaling pathways of Interleukin 6 (IL-6)-STAT3, Tumor necrosis factor alpha (TNF-α) -NFκB and Interferon gamma (IFNγ) -GAS activity as well as the stimulation of Dexamethasone (Dexa) -GRE activity are all involved in anti-inflammatory response1–16.