RBM3 (P98179, RNPL) was among sets of RNA-binding proteins (RNA-BPs) detected in invasive pseudopodia of mesenchymal breast cancer cells30, and in subcellular specializations termed spreading initiation centers (SICs)31 that form during the initial stage of cell spreading in fibroblasts and many mesenchymal cell lines32. This evidence concerns the gene RBM3 and breast cancer.