Guinney et al. 12 proposed to categorize CRC into 4 consensus molecular subtypes (CMS); the CMS1 (14%) called MSI-like corresponds to CRC tumors with mutations in mismatch repair (MMR) genes, such as MLH1 and is also enriched in the CpG island methylation phenotype (CIMP). This evidence concerns the gene MLH1 and colorectal carcinoma.