Over-enrichment of mutations in cancer drivers is seen in CMS1, with the exception of the 2 tumor suppressor genes APC and TP53. APC mutations are significantly enriched in CMS2, while TP53 mutations are enriched both in CMS2 and CMS4 subtypes, highly associated with CIN status. The gene discussed is TP53; the disease is cervical squamous intraepithelial neoplasia.