Our group was the first to determine the gene status of nine APC/C subunits (APC2, APC3, APC4, APC5, APC6, APC7, APC8, APC10 and APC11) in cancer cells of different human tissue origins, and identified the presence of several heterozygote mutations in platform and TPR arm subunits genes (APC4, APC6 and APC8) in cell lines of CRC origin25. Here, APC is linked to cancer.