Among the 25 previously validated glioma risk loci, nine loci contained 10 SNPs with pM < 2.8 × 10−6 and/or pF < 2.8 × 10−6 in any histology: 1p31.3 (RAVER2), 5p15.33 (TERT), 7p11.2 (EGFR, two independent loci), 8q24.21 (intergenic region near MYC), 9p21.3 (CDKN2B-AS1), 11q23.3 (PHLDB1), 16p13.3 (RHBDF1), 17p13.1 (TP53), and 20q13.33 (RTEL1) (Table 2). The gene discussed is PHLDB1; the disease is central nervous system cancer.