Univariate analysis showed that the composite endpoint was significantly associated with sex, hypertension, UPE, eGFR, hyperuricaemia, serum levels of complement C4, mesangial hypercellularity, endocapillary hypercellularity, segmental sclerosis, tubular atrophy or interstitial fibrosis, crescents, glomerulosclerosis and administration of RASI. Here, C4A is linked to glomerulosclerosis.