INS and Insulin resistance: Antipsychotic naive FEP is associated with elevated fasting glucose, glucose following the oral glucose tolerance test, fasting insulin, and insulin resistance (effect size range 0.20–0.61), raised triglycerides (effect size: 0.14), and reduced total cholesterol and LDL cholesterol (effect size range: −0.22 to −0.19) (Fig. 1a).