Hereby, we found that ATX inhibition by PF8380 effectively rescued PPI startle responses in this animal model of schizophrenia to wild-type levels (Fig. 3d and Fig S4D) and significantly reduced locomotor hyperactivity, which is a schizophrenia-resembling positive symptom and was characteristically displayed after ketamine application (Fig 3e). Here, ENPP2 is linked to schizophrenia.