In contrast, a combination of GADD45α overexpression (Fig. 5a) and IR treatment dramatically suppressed tumor growth (Fig. 5b), with significant inhibition of cell proliferation (Fig. 5c) and induction of cell apoptosis (Fig. 5d) compared to both controls and a single treatment of IR or GADD45α overexpression alone in the HeLa-XR xenograft model. Here, GADD45A is linked to neoplasm.