miR-26a, miR-34a and miR-146a suppress HCC cell progression by targeting fucosyltransferase 8 (FUT8), the only enzyme responsible for β1,6-fucosylation of N-glycans14; O-GlcNAc transferase (OGT) was identified as a novel target of miRNA-7 in a mouse glioblastoma xenograft model15 and of miR-24-1 in human breast cancer cells16; mature miR-17-5p and passenger miR-17-3p induce HCC by targeting N-acetylgalactosaminyltransferase 7 (GALNT7)17; Let-7c inhibits metastatic ability of mouse hepatocarcinoma cells via targeting mannoside acetylglucosaminyltransferase 4 isoenzyme A (Mgat4a)11. This evidence concerns the gene FUT8 and hepatocellular carcinoma.