RUNX2 and hepatocellular carcinoma: After predicting transcription factors that may bind to the miR-23a promoter region by online bioinformatics analysis31,32, we focused on Runx2, which showed positive correlation with metastasis35,36 in HCC and found a positive correlation between Runx2 expression and miR-23a~27a~24-2 cluster levels in these two mouse HCC cell lines (Figs 1b and 4a).