FERMT2 and breast cancer: In the MDA-MB-231 BC model, we found the number of lung nodules, which represent the metastasis foci, was reduced by more than 10-fold (p < 0.01) in mice implanted with the Kindlin-2-deficient (Kindlin-2 CRISPR) cells compared to their control (Scram CRISPR) counterparts (Fig. 3A,B).