The finding from this study on the role of Kindlin-2 in the regulation of the metastasis phenotype is a continued effort that was built upon our recently published data that demonstrated a key role for Kindlin-2 in the modulation of the tumour microenvironment to support BC growth and progression13, as well as its involvement in the molecular mechanisms of tumour resistance to therapy36. This evidence concerns the gene FERMT2 and neoplasm.