Coadministration of ruxolitinib together with IFN-γ at 48 h prior to infection (data not shown) as well as IFN-γ preincubation followed by ruxolitinib addition at the time point of infection, thereby phenocopying the presence of the Jak-STAT inhibitor pM27, completely reverted the pronounced antiviral activity of IFN-γ and normalized ΔM27-MCMV replication to wt-MCMV levels (Fig. 3B). The gene discussed is IFNG; the disease is infection.