In contrast, there were significant increases in both CIS and RRMS plasmablasts, with none detected in the OND cohort (figure 4A), consistent with previous reports.20 There were significant increases in IgG+ B cells in the CSF as compared with blood, suggesting exclusion of IgA+ B cells (figure 4B, online Supplementary figure e1). The gene discussed is CD79A; the disease is in situ carcinoma.