Khattar et al. discovered that the increased TERT gave rise to proliferative abilities of cancer cells in melanoma, because TERT upregulated tRNA expression by its direct combination with RNA polymerase III subunit RPC32 and enhanced recruitment of chromatin resulting in an increase in the occupancy rate of RNA pol III on the tRNA gene, suggesting that TERT promoted cancer cell proliferation by augmenting tRNA expression, such as tRNAArg, tRNAAla, tRNAAsn, tRNACys, tRNALys, tRNAGlu and tRNAThr [62]. This evidence concerns the gene TERT and cancer.