It is unexpected that the synthesis of tRNA is controlled by all kinds of oncogenes and tumor suppressors—Ras [27] and c-myc [28] promote the transcription of RNA Pol III, whereas Rb [29] and p53 [30] inhibit RNA Pol III transcription, causing the serious dysregulation of tRNA level in a wide range of cancers. The gene discussed is MYC; the disease is cancer.