ERBB2 and cancer: Recent studies suggested that all tRNALeu isoacceptors were more highly expressed only in human epidermal growth factor receptor-2 (Her2) -positive breast subtypes, but not in other subtypes, which greatly promoted the proliferation of cancer cells and their resistance to death via interaction of tRNALeuCAG with ErbB3-binding protein 1 (EBP1), subsequently enhancing the activation of ErbB2/ErbB3 pathway and the RSK1/MSK2 signaling pathway [65].