BMPR2 and heritable pulmonary arterial hypertension: Our results showed that 37 BMPR2 mutations (37/49, 75.5%) were identified in 32 IPAH and 5 HPAH by the sequencing methods and 12 BMPR2 CNVs (12/49, 24.5%) were indicated from the panel data and finally validated by MLPA, which was distinct from Cogan’s report [8] that a higher frequency of BMPR2 mutation was detected by deletions/duplications analysis in HPAH, compared with that by sequence analysis (48% vs. 37%).