Therefore, the study concludes that a low-protein dietary supplemented with ketoacids reduces the accumulation of protein wasting products and ameliorates the glucose control improving the insulin sensitivity in diabetic CKD patients; furthermore, the study undoubtedly demonstrates that such restricted diet in the long term does not worsen the nutritional status and preserves the body composition avoiding the onset of sarcopenia in diabetic patients with CKD. This evidence concerns the gene INS and chronic kidney disease.