In multivariable analysis, female sex (p = 0.01), Charlson comorbidity index (p < 0.001), and ST2 (p = 0.001) were the only independent variables associated with the primary composite endpoint (Table 2) and also with HF-related rehospitalization [female sex (p = 0.04), Charlson comorbidity index (p = 0.003), and ST2 (p = 0.008)] (Additional file 2: Table S2). Here, IL1RL1 is linked to hydrops fetalis.