IL10 and cancer: Moreover, IL-35-producing B cells were positively associated with Treg cells, MDSCs, IL-10-producing B cells, and CD14+ monocytes during the progression of GC, which indicates that the suppression of IL-35-producing B cells in GC may occur through interaction with other immunosuppressive cells, such as Treg cells and MDSCs, which participate in the immunosuppressive response in cancer.