Moreover, IL-35-producing B cells were positively associated with Treg cells, MDSCs, IL-10-producing B cells, and CD14+ monocytes during the progression of GC, which indicates that the suppression of IL-35-producing B cells in GC may occur through interaction with other immunosuppressive cells, such as Treg cells and MDSCs, which participate in the immunosuppressive response in cancer. This evidence concerns the gene CD14 and cancer.