An investigation reported that LAP and VAI were markers of insulin resistance and metabolic-related disturbances in young women with polycystic ovary syndrome.[39] Recent meta-analysis investigated the effects of saturated fat, polyunsaturated fat, monounsaturated fat, and carbohydrate on glucose-insulin homeostasis.[40] It reported that only energy intake substitution with PUFA was associated with lower fasting glucose, lower HbA1c, improved HOMA-IR, and improved insulin secretion capacity. The gene discussed is INS; the disease is Insulin resistance.