Lin28a, the transcriptional target of Sp-1, which couldfurther elevate the levels of certain cancer-related miRNAs (24), was also suppressed by urolithin A in HepG2.2.15 cells.Therefore, we speculated that suppression of Sp-1 could be responsible for thedecrease of Lin28a by urolithin A. The gene discussed is SP1; the disease is cancer.