Using a panel of PCa cells, including cell lines from AAM, we also elucidated that exogenous IL‐6 upregulated expression of the epigenetic reader methyl CpG binding domain protein 2 (MBD2), specifically the alternative mRNA splicing variant MBD2_v2, to promote cancer stem‐like cells (CSCs). Here, MBD2 is linked to posterior cortical atrophy.