A notable number of DNA‐interacting enzymes are listed in the ligand‐based VP for metformin (Table 1), including geminin, an inhibitor of replication initiation that prevents DNA rereplication‐driven genomic instability and cellular senescence, DNA polymerase iota, and flap endonuclease 1, a key interaction partner of the RecQ helicases involved in genome maintenance and DNA metabolism during accelerated aging genetic disorders and cancer. This evidence concerns the gene POLI and hereditary disease.