The post hoc analysis of the PIONEER AF-PCI trial demonstrated that AF patients who underwent PCI and were treated with rivaroxaban 15 mg q.d. plus a P2Y12 inhibitor for 12 months or rivaroxaban 2.5 mg b.i.d. plus DAPT for 1, 6 or 12 months had a lower risk of all-cause mortality or recurrent hospitalisation for adverse events compared to those with VKA plus DAPT for 1, 6 or 12 months [17]. This evidence concerns the gene P2RY12 and atrial fibrillation.