DUOX1 and clear cell renal carcinoma: Similarly, the most recurrent CNV changes in tumors were found as amplifications in the promoters of DUOX1, a NADPH oxidase involved in the maintenance of tissue homeostasis (47), as well as CLIP4, an intracellular linker protein whose knock-down has been shown to increase cell migration and viability in clear cell renal cell carcinomas (48).