Indeed, we have observed increased methylation in the promoters of several tumor suppressor genes including APC (Figure S3 in Supplementary Material), a well-characterized tumor suppressor gene associated with familial adenomatous polyposis, and KLK10, which has been shown to repress proliferation and induce apoptosis in PCa cells (36). This evidence concerns the gene KLK10 and Familial adenomatous polyposis.