SP4 and neoplasm: Except for few being chromatin regulators (CGBP, MBD2, and DNMT1), all of these TFs were found to have tumor suppressor functionality (BRCA1, E2F1&2&5&7, EGR1-4, FLI1, NRF1, TFDP2, and STAT1), or indirectly mediate the suppression of tumorigenesis and tumor suppressor activity (SP4 and ZBTB33).