Similarly, the most recurrent CNV changes in tumors were found as amplifications in the promoters of DUOX1, a NADPH oxidase involved in the maintenance of tissue homeostasis (47), as well as CLIP4, an intracellular linker protein whose knock-down has been shown to increase cell migration and viability in clear cell renal cell carcinomas (48). The gene discussed is FMO5; the disease is clear cell renal carcinoma.