However, no major differences in clinical parameters were seen at baseline between seronegative patients, patients with 1–3 antibodies and patients with 4 or more antibodies—a pattern highly specific for RA, even in the absence of IgG-ACPA—except that TJC28 was significantly lower in patients with 4 or more antibodies compared to seronegative patients. The gene discussed is PRTN3; the disease is rheumatoid arthritis.