Besides TCR-dependent sensing of intracellular PAg accumulation, the discrimination between tumor and healthy cells by Vγ9Vδ2 T cells seemingly also involves NKG2D, which is expressed on the cell surface of nearly all Vγ9Vδ2 T cells, as it is on peripheral CD8+ αβ T cells. Here, KLRK1 is linked to neoplasm.