NCR3 and neoplasm: Interestingly, while the presence of B7-H6 on the surface of tumor cells makes them susceptible to NKp30-mediated killing (67), the binding of B7-H6 to the alternative splice variant, NKp30c, reduces cytotoxicity and IFN-γ production, instead inducing NK cells to produce the immunoregulatory cytokine IL-10 (68).