The CFH(H3)-CFHR3*B–CFHR1*B haplotype also carries the CFH (rs1065489; p936D<E) and CFHR3 variants (rs385390, rs426736, and rs371075) that were shown to confer protection against meningococcal disease (33); quantitation of FHR-3 levels and CFHR3*A/B/Del genotyping in these patients will likely help establish the actual relationship between this haplotype and protection against N. meningitidis infection. The gene discussed is CFHR3; the disease is meningococcal infection.