In the pemphigus foliaceus (PF) subgroup, only antibodies against Dsg1 are present, whereas in pemphigus vulgaris (PV) antibodies against Dsg3 are found in mucosal dominant PV (mdPV), or together with anti-Dsg1 in mucocutaneous PV (mcPV) (2). The gene discussed is DSG1; the disease is pemphigus foliaceus.