ANGPT2 and Sepsis: Importantly, Ang2 levels measured early in the course of sepsis, including within 24 h of symptoms onset (158, 163, 166, 168), presentation to an Emergency Department (56, 150), and admission to ICU (50, 53, 60, 155, 157, 159, 160, 162, 164, 165), were associated with disease severity and predicted hospital mortality.