Reduced Tie2 activation during sepsis is the result of several perturbations to the pathway, including decreased Tie2 and Ang1 expression (24, 54, 57, 90–92), generation of soluble Tie receptors (14, 15, 40, 41, 66, 93, 94), and the antagonistic activity of Ang2 (14, 15). Here, ANGPT2 is linked to Sepsis.