KLRK1 and autoimmune disease: Later on, NKG2D+ CD4+ T cells have been associated with several other autoimmune diseases, such as Crohn’s disease (108, 113, 114), Wegener granulomatosis (115, 116), type 2 diabetes (117), multiple sclerosis (118), and systemic lupus erythematosus (SLE) (119, 120).