In order to evaluate the impact of septicemia on different populations of DCs, Flohé and his collaborators used a mouse CLP model, and they distinguished CD11c+ cells on the basis of expression of CD8 (expressed by cDC1) and CD4 (expressed by cDC2), from double-negative cells that might be cDC precursors, for example (108). The gene discussed is ITGAX; the disease is Sepsis.