Deletion of Lyn selectively in B cells using Mb1-Cre to induce deletion from a floxed allele of Lyn is sufficient to induce ANAs and glomerulonephritis (57), and similar phenotypes are found in CD22−/− mice (58), FcγRIIb−/− mice (59), and mice with a B cell-specific deletion of the gene encoding SHP-1 (54). This evidence concerns the gene LYN and glomerulonephritis.