In addition, the role of FcγRs and different molecular events in ADE like inhibition of STAT1, IFN signaling, nitric oxide (NO) production, retinoic acid-inducible gene (RIG)-1, and melanoma differentiation-associated gene (MDA)-5 gene expression, as well as the roles of IL-10 upregulation, autophagy, and hypoxia in ADE are discussed. This evidence concerns the gene IFIH1 and acute disseminated encephalomyelitis.