These findings suggest that the role of KCNQ1 in the maintenance of the hypothalamic–pituitary axis integrity is not necessarily associated with the electrical activity of the KCNQ1–KCNE channels, and underscore the fact that to date only the codons 116 and 369 link KCNQ1 to pituitary hormone deficiency (4). The gene discussed is KCNQ1; the disease is hypopituitarism.