INS and type 2 diabetes mellitus: The practical difficulty in procuring samples to test blood glucose and serum insulin levels, the intra-individual variability in blood glucose levels (4), the high-risk familial genes adding no value in predicting the onset of the disease (5), and the fact that only 20% of the obese individuals are actually at a risk of developing full-blown T2DM (6) limits the use of existing biomarkers.