A panel of 64 circulating candidate biomarkers was analyzed to develop a model for the assessment of a 5-year risk of developing T2DM and identified six biomarkers including adiponectin, CRP, ferritin, interleukin-2 receptor A, and insulin that provide a better estimation of the risk of developing T2DM than that of FPG levels alone (93). This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.