However, these preliminary in vitro studies suggesting insulin resistance induced by SGAs were confirmed and further characterized in rats by Martins and coworkers (34), who demonstrated that olanzapine administered directly to the CNS induces the expression of hypothalamic 5′ adenosine monophosphate-activated protein kinase and hepatic insulin resistance, suggesting a CNS target for the metabolic dysregulation of atypical antipsychotics. The gene discussed is INS; the disease is Insulin resistance.