So far, more than 180 potential genetic risk factors have been identified, including mutations in SOD1 (Cu/Zn superoxide dismutase 1), TDP-43 (TAR DNA-binding protein 43), FUS (fused in sarcoma/translated in liposarcoma), and an increased number of repeats in C9ORF72 (2). Here, TARDBP is linked to sarcoma.