INSL3 and hypospadias: The fact that INSL3 and androstenedione (both Leydig cell biomarkers) are closely correlated in the weeks 13–16 samples (cases and controls combined) and that also androstenedione shows an increased variance (Levene’s test), if not mean, in the hypospadias cases reinforces this notion, that there is a larger ‘at risk’ population amongst the cases compared to controls.