Mohan et al. (2017) explored the capacity of epigallocatechin-3-gallate to prevent apoptosis in rats on a high-fat diet and with STZ-induced diabetic nephropathy, demonstrating an improvement in renal function by the downregulation of TGF-β, ameliorating their diabetic nephropathy. The gene discussed is TGFB1; the disease is diabetic kidney disease.