AD is clinically characterized by progressive memory loss and cognitive dysfunction and neuropathologically characterized by extracellular deposition of amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles (NTFs) composed of hyperphosphorylated tau proteins (Alzheimer’s Association, 2011; Ballard et al., 2011). The gene discussed is MAPT; the disease is Alzheimer disease.