Several lines of evidence indicate that the deposition of Aβ aggravates phosphorylated tau and affects the surrounding central nervous system (CNS) resident cells, such as microglia, oligodendrocytes and neurons, ultimately causing neuroinflammation, neurodegeneration, and neuronal loss in AD pathologies (Götz et al., 2001; Cunningham, 2013; Zempel et al., 2013). Here, MAPT is linked to Alzheimer disease.