Davies et al. (2006) have suggested that SNPs in 5-HT2A in their study that lower 5-MeO-DMT's potency may be the genetic basis of such differential response to psychedelics and that individuals who do not bear these mutations and are susceptible to psychosis have an increased likelihood of exacerbation of its development following the use of psychedelics. The gene discussed is HTR2A; the disease is psychotic disorder.