Based on the network and multi-target computational approach, we found that simultaneous manipulation of multiple targets involved in proliferation, such as epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (HGFR), peroxisome proliferator-activated receptors (PPARs), ERBB2, and insulin-like growth factor 1 receptor (IGF1R), as well as angiogenesis, such as VEGF receptor (VEGFR), might underlie the beneficial effects of the 18 herbs in CRC. The gene discussed is EGFR; the disease is colorectal carcinoma.