Based on the network and multi-target computational approach, we found that simultaneous manipulation of multiple targets involved in proliferation, such as epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (HGFR), peroxisome proliferator-activated receptors (PPARs), ERBB2, and insulin-like growth factor 1 receptor (IGF1R), as well as angiogenesis, such as VEGF receptor (VEGFR), might underlie the beneficial effects of the 18 herbs in CRC. This evidence concerns the gene MET and colorectal carcinoma.