Collectively, our results showed that 18 herbs in CHM might exhibit anti-CRC activity mainly via 1) inhibition of the proliferative activity of ERBB2, PPARγ, and RXR; 2) suppression of angiogenesis by inhibiting VEGFR and VEGFA expression; 3) inhibition of the PI3K/AKT1 signaling pathway directly through SRC and AKT1; and 4) Reduction of TNF-induced inflammation. Here, VEGFA is linked to colorectal carcinoma.