In contrast, CAD had a similar strength of association with both the APOE-ε4 variant (rs429358, OR [95% CI]: 1.10 [1.06–1.13]; p = 2.17 × 10−9; EA = C) and APOE-ε2 variant (rs7412, OR [95% CI]: 1.15 [1.10–1.20]; p = 8.17 × 10−11; EA = C)5. The gene discussed is APOE; the disease is coronary artery disorder.