Exploration of potentially pleiotropic effects in each of the 52 variants for CAD (eTable 7) suggest that LDL cholesterol is unlikely to be involved in any shared biological pathways between LOAD and CAD, other than via the effects of APOE. Among the 10 CAD loci that were associated with significant differences in LDL-cholesterol concentrations, only one of these (APOE) was also associated with LOAD. Here, APOE is linked to coronary artery disorder.