APOE and coronary artery disorder: Furthermore, the APOE-ε2 (rs7412) has been associated with LDL cholesterol concentrations (effect size [SD units, per C allele] [95% CI]: 0.59 [0.57–0.61]; p = 1.24 × 10−652)13, and rs4420638 (D′ = 1 with rs7412) was associated with a 10% higher risk of CAD (OR [95% CI]: 1.10 [1.07–1.13])5.