Chen J. et al. 19 found that WISP1 rs16893344, rs2977530, rs2977537, and rs62514004 (P < 0.05) polymorphisms were related to susceptibility of lung cancer; and WISP1 rs11778573, rs16893344, rs2977536, rs2977549 and rs62514004 polymorphisms were significantly associated with platinum-based chemotherapy response in lung cancer patients. This evidence concerns the gene CCN4 and lung carcinoma.