Interestingly, Tomohiko et al. 16 evaluated the association of a SNP (rs2929970) in the WISP1 3′-UTR region with the presence of osteophytes, endplate sclerosis, and narrowing of disc spaces for spinal osteoarthritis in 304 postmenopausal Japanese women and found strong associations of rs2929970 with endplate sclerosis. Here, CCN4 is linked to exostosis.