TGFB1 and wet macular degeneration: TGF-β is the most important of these factors and has been implicated in numerous ocular fibrosis including corneal opacification, pterygium, posterior capsular opacification, proliferative vitreoretinopathy, fibrovascular membrane formation in proliferative diabetic retinopathy, subretinal fibrosis in neovascular age-related macular degeneration, and conjunctival fibrosis following glaucoma filtration surgery24.