Pathogenic mechanisms proposed to underlie delayed gastric emptying in DM include autonomic neuropathy, loss of neuronal nitric oxide synthase (nNOS) expression, loss of interstitial cells of Cajal (ICC), low level of antioxidant heme oxygenase-1, and loss of CD206-positive anti-inflammatory macrophages4–15. The gene discussed is NOS1; the disease is diabetes mellitus.