Here we used both pharmacologic and genetic approaches to demonstrate the requirement for TRPV1 in post-UTI chronic pelvic pain initiated by infection with the K12 strain SΦ874 (Figs 1 and 2), a strain shown to cause chronic allodynia that persists for weeks and months (ref.6 and Rudick and Klumpp, unpublished observations). This evidence concerns the gene TRPV1 and bacterial urinary tract infection.