Together, these results imply that arterial-type CD144+CD43−CD73−DLL4+ HE represents the precursor of definitive NOTCH-dependent hematopoiesis with broad lympho-myeloid and definitive erythroid potential, while the CD144+CD43−CD73−DLL4− phenotype is associated with emerging immature HE endothelium (D4) or HE that has primitive NOTCH-independent hematopoietic potential (D5). Here, CDH5 is linked to hereditary elliptocytosis.