CDKN2A and carcinoma: Based on the analysis of the validated somatic genetic alterations, the adenomyoepithelioma and carcinoma components of the primary tumor and the axillary lymph node metastasis shared 11 clonal truncal mutations, including an HRAS and two PIK3R1 mutations, and a CDKN2A homozygous deletion (Fig. 4c, Supplementary Data 3), and truncal CNAs including losses of 9p and 9q.