While PIK3CA mutations are common in breast cancer (approximately 35%), mutations in AKT1 and HRAS were found to be significantly less frequent in unselected breast cancers than in the adenomyoepitheliomas studied here (P < 0.05, Fisher’s exact tests, Fig. 3b, Supplementary Data 4)6,7. The gene discussed is PIK3CA; the disease is breast carcinoma.