Of note, recurrent homozygous deletions affecting CDKN2A were found in 3/14 (21%) ER-negative adenomyoepitheliomas (Fig. 2, Supplementary Fig. 3f) and, interestingly, these three cases were found to progress to carcinoma (100% versus 9%, P = 0.011, Fisher’s exact test). This evidence concerns the gene CDKN2A and carcinoma.