To confirm the relation between miR-181a and SRCIN1, in situ hybridization revealed that miR-181a was higher expression and IF showed that SRCIN1 was downregulated in CRC compared with normal tissues (Fig. 3e).Thus, we speculated that the upregulation of miR-181a expression may be responsible for the decreased expression level of SRCIN1 in human CRC tissues, which promotes angiogenesis in CRC. Here, SRCIN1 is linked to colorectal carcinoma.